반응 #83232

반응 방정식

2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

hydrochloric acid

→

2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   농축The resulting clear solution was concentrated in vacuo
2. 2
   workup.ADDITIONTo the residue was added ethanol (1 ml)
3. 3
   농축the solution was concentrated in vacuo
4. 4
   기타The residue was crystallized from a mixture of methanol (0.5 ml) and ethyl acetate (3 ml)
5. 5
   기타recrystallized from an aqueous isopropyl alcohol solution

실험 절차

To a suspension of 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (250 mg) in ethanol (3.5 ml) was added 1N hydrochloric acid (0.85 ml). The resulting clear solution was concentrated in vacuo. To the residue was added ethanol (1 ml) and the solution was concentrated in vacuo. The residue was crystallized from a mixture of methanol (0.5 ml) and ethyl acetate (3 ml) and recrystallized from an aqueous isopropyl alcohol solution to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride (233 mg).

출처