반응 #83224

반응 방정식

5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole

methyl acrylate

pyridine

→

2-(4-fluorophenyl)-5-oxo-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

용매

water

반응 조건

후처리

1. 1
   온도was refluxed for 8 hours
2. 2
   온도The mixture was cooled
3. 3
   농축concentrated in vacuo
4. 4
   workup.DISSOLUTIONThe residue was dissolved in a mixture of acetic acid (10 ml) and concentrated hydrochloric acid (1.5 ml)
5. 5
   온도The solution was refluxed for 2 hours
6. 6
   온도cooled
7. 7
   기타The separated solid was collected
8. 8
   세척washed with water
9. 9
   기타dried

실험 절차

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (1.016 g), methyl acrylate (10 ml), pyridine (20 ml) and water (5 ml) was refluxed for 8 hours. The mixture was cooled and concentrated in vacuo. The residue was dissolved in a mixture of acetic acid (10 ml) and concentrated hydrochloric acid (1.5 ml). The solution was refluxed for 2 hours, cooled and neutralized with an aqueous saturated sodium bicarbonate solution. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-5-oxo-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (750 mg).

출처