반응 #83220

반응 방정식

2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine

hydrogen chloride

→

2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

용매

methanol

반응 조건

후처리

1. 1
   농축The resulting clear solution was concentrated in vacuo
2. 2
   workup.ADDITIONTo the residue was added ethanol (3 ml)
3. 3
   농축the solution was concentrated in vacuo
4. 4
   기타The residue was crystallized from a mixture of ethanol and diethyl ether

실험 절차

To a suspension of 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (100 mg) in methanol (2 ml) was added 10% methanolic hydrogen chloride (0.5 ml). The resulting clear solution was concentrated in vacuo. To the residue was added ethanol (3 ml) and the solution was concentrated in vacuo. The residue was crystallized from a mixture of ethanol and diethyl ether to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride (100 mg).

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