반응 #83213

반응 방정식

water

4-fluorophenylacetonitrile

ethyl isonicotinate

Sodium

→

2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

용매

ethanol

반응 조건

후처리

1. 1
   온도the solution was refluxed for 3 hours
2. 2
   온도The reaction mixture was cooled
3. 3
   기타The ethanol of the mixture was removed under reduced pressure
4. 4
   세척The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid
5. 5
   기타The separated solid was collected
6. 6
   세척washed with water
7. 7
   기타dried

실험 절차

Sodium (2.48 g) was dissolved in dry ethanol (37 ml) under nitrogen atmosphere. To the solution was added 4-fluorophenylacetonitrile (11.65 g) and ethyl isonicotinate (16.41 ml) and the solution was refluxed for 3 hours. The reaction mixture was cooled and poured into water. The ethanol of the mixture was removed under reduced pressure. The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (16.43 g).

출처