반응 #8314

반응 방정식

4-benzyl-dihydrofuran-2-one

HBr

→

3-benzyl-4-bromo-butyric acid

용매

acetic acid

반응 조건

후처리

1. 1
   온도The mixture is cooled to room temperature
2. 2
   추출extracted with chloroform (2×30 mL)
3. 3
   세척The combined organic extracts are washed with water and brine
4. 4
   건조dried with anhydrous sodium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

A mixture of 4-benzyl-dihydrofuran-2-one (1.0 g, 5.6 mmol), acetic acid (1.7 mL), HBr (33% in acetic acid, 2.0 mL) is heated at 80° C. for 4 h. The mixture is cooled to room temperature, poured into ice-water (20 mL), and extracted with chloroform (2×30 mL). The combined organic extracts are washed with water and brine, dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo to yield 3-benzyl-4-bromo-butyric acid, 1.5 g (99%), as a colorless liquid.

출처