반응 #83129

반응 방정식

2-adamantyloxycarbonyl-α-methyl-DL-tryptophan

1H-benzimidazole-2-ethanamine dihydrochloride

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title compound

Tricyclo[3.3.1.13,7 ]dec-2-yl (±)-[2-[[2-(1H-benzimidazol-2-yl)ethyl]amino]-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl]carbamate

용매

triethylamine

반응 조건

후처리

1. 1
   기타The purified product after chromatography was obtained as a white foam, 0.38 g (56%)

실험 절차

Following the procedure of Example 70, the title compound was prepared from 0.50 g (1.26 mmol) of 2-adamantyloxycarbonyl-α-methyl-DL-tryptophan and 0.33 g (1.41 mmol) of 1H-benzimidazole-2-ethanamine dihydrochloride with 0.5 mL of added triethylamine. The purified product after chromatography was obtained as a white foam, 0.38 g (56%); 1H NMR (CDCl3) δ1.46-1.91 (17H, m), 3.01-3.16 (2H, m), 3.27 (1H, d, J 15 Hz), 3.43 (1H, d, J 15 Hz), 3.58 (2H, m), 4.80 (1H, br s), 5.23 (1H, s), 6.67 (1H, m), 6.89-7.72 (10H, m), 8.28 (1H, br s).

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