반응 #83080

ord-b6e416514e594b8e820659524d266299

반응 방정식

COc1ccc(CSC2CC(CO)S(=O)(=O)C2)cc1
product
COc1ccc(CSC2CC(CO)S(=O)(=O)C2)cc1
Tetrahydro4-[[(4-methoxyphenyl)methyl]thio]-2-thiophenemethanol-1,1-dioxide
COc1ccccc1
anisole
CC(=O)O
acetic acid
→
O=S1(=O)CC(S)CC1CO
desired product
수율 86.9%
O=S1(=O)CC(S)CC1CO
Tetrahydro-4-mercapto-2-thiophenemethanol 1,1-dioxide
수율 86.9%

반응물

—
mercuric trifluoroacetate
COc1ccc(CSC2CC(CO)S(=O)(=O)C2)cc1
product
COc1ccc(CSC2CC(CO)S(=O)(=O)C2)cc1
Tetrahydro4-[[(4-methoxyphenyl)methyl]thio]-2-thiophenemethanol-1,1-dioxide
COc1ccccc1
anisole
CC(=O)O
acetic acid

시약

없음

용매

CCCCCC.CCOC(C)=O
ethyl acetate hexane

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타to give

실험 절차

The title compound is prepared by the procedure of Example 202 using 0.615 g of product from Example 177, 1.04 g of mercuric trifluoroacetate, 0.440 g of anisole and 31 ml of 80% acetic acid to give, after chromatography (Silica gel: 10-100% ethyl acetate/hexane), 0.322 g of the desired product.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05623081uspto-grants-1997_04