반응 #83066

반응 방정식

product

Ethanethioic acid S-[tetrahydro-5-[(phenylmethoxy)methyl]-3-thienyl]ester

boron trifluoride etherate

→

desired product

수율 94.3%

Ethanethioic acid S-[tetrahydro-5-(hydroxymethyl)-3-thienyl]ester

수율 94.3%

용매

chloroform

반응 조건

후처리

1. 1
   농축concentrated in vacuo
2. 2
   기타The residue is purified by chromatography (silica gel: 0-100% ethyl acetate/hexane)

실험 절차

A 0° C. solution, under argon, of 0.123 g of product from Example 139 in 1.0 ml of dry chloroform is treated with 51.1 microliter of boron trifluoride etherate and 0.193 g of tetra n-butylammonium iodide. The reaction mixture is stirred at room temperature overnight and concentrated in vacuo. The residue is purified by chromatography (silica gel: 0-100% ethyl acetate/hexane) to give 0.079 g of the desired product.

출처