반응 #8301

반응 방정식

1-fluoronaphthalene

paraformaldehyde

phosphoric acid

hydrochloric acid

acetic acid

→

title compound

1-Chloromethyl-4-fluoronaphthalene

용매

water

반응 조건

후처리

1. 1
   추출extracted three times with dichloromethane
2. 2
   세척washed with water and brine
3. 3
   건조dried (sodium sulfate)
4. 4
   여과filtered
5. 5
   기타evaporated

실험 절차

A solution of 1-fluoronaphthalene (5.5 g, 37.6 mmol), paraformaldehyde (2.5 g, 83 mmol), glacial acetic acid (3.5 mL), phosphoric acid (2 mL) and concentrated hydrochloric acid (5 mL) is heated at 85° C. for 15 h. The reaction mixture is poured into water and extracted three times with dichloromethane. The organic extracts are combined and washed with water and brine, dried (sodium sulfate), filtered, and evaporated to yield the title compound, 6.53 g (98%, as a yellow solid.

출처