반응 #82982

반응 방정식

bromide

2-amino-1-(2-piperidinoethyl)-3-(2-thenoylmethyl) benzimidazolium bromide

water

acetic anhydride

→

2-Methyl-9-(2-piperidinoethyl)-3-(2-thenoyl)imidazo [1,2-a]benzimidazole

반응 조건

후처리

1. 1
   workup.DISSOLUTIONuntil completely dissolved
2. 2
   온도Cool
3. 3
   추출Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time
4. 4
   기타evaporate
5. 5
   기타Recrystallise the residue from ethyl acetate

실험 절차

The bromide obtained in Step A is heated at reflux in 15 ml of acetic anhydride until completely dissolved. Cool and pour into 50 ml of cold water. Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time. Combine the organic phases, pass over a column of alumina and evaporate. Recrystallise the residue from ethyl acetate.

출처