반응 #82974

반응 방정식

5-bromo-2-bromoacetylthiophene

2-amino-1-(2-piperidinoethyl)-benzimidazole

→

title compound

수율 82.0%

2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide

수율 82.0%

용매

ether

acetone

반응 조건

후처리

1. 1
   여과Suction-filter the precipitate
2. 2
   세척wash with acetone

실험 절차

Add a solution of 5-bromo-2-bromoacetylthiophene (5.68 g, 20 mmol) in 30 ml of ether to a hot solution of 2-amino-1-(2-piperidinoethyl)-benzimidazole (4.88 g, 20 mmol) in 150 ml of acetone. Stir and maintain at room temperature for five hours. Suction-filter the precipitate, wash with acetone and then with ether to obtain the title compound.

출처