반응 #828725
ord-82cf42276e5e4f7ebfb38c6155add346
반응 방정식
2-isopropylthiobenzoyl chloride
3-hydroxyoxetane
pyridine
→
oxetan-3-yl 2-isopropylthiobenzoate
수율 89.0%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The suspension formed
- 2세척Adding water to the reaction mixture, washing the organic phase with water
- 3기타drying
- 4기타evaporating it
실험 절차
A mixture of 12.9 g of 2-isopropylthiobenzoyl chloride and 20 ml of absolute toluene is added dropwise to a mixture of 4.44 g of 3-hydroxyoxetane, 6.64 g of pyridine and 60 ml of absolute toluene at a temperature of 15° to 20° C. The suspension formed is stirred at a temperature of 20°-25° C. for 2 hours and at a temperature of 40°-45° C. for a further 3 hours. Adding water to the reaction mixture, washing the organic phase with water and drying and evaporating it gives 12.6 g of oxetan-3-yl 2-isopropylthiobenzoate as a pale yellow oil.