반응 #8287

반응 방정식

2-hydroxyaceto-phenone

pyridine

acetic anhydride

→

title compound

Acetic Acid 2-oxo-2-phenyl-ethyl ester

용매

dichloromethane

반응 조건

후처리

1. 1
   세척The mixture is washed with water (200 mL) and brine (200 mL)
2. 2
   건조then dried over sodium sulfate
3. 3
   여과The mixture is filtered
4. 4
   농축concentrated in vacuo

실험 절차

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

출처