반응 #82867

반응 방정식

ethylacetate

N-(4-acetyl-3-hydroxy-phenyl)acetamide

2-bromo-4-methylacetophenone

potassium carbonate

→

N-[3-Methyl-2-(4-methyl-benzoyl)-benzofuran-6-yl]acetamide

용매

DMF

반응 조건

후처리

1. 1
   세척The organic phase was washed three times with water, one time with a NaCl solution
2. 2
   건조dried over Na2SO4
3. 3
   농축concentrated in vacuo
4. 4
   기타The residue was further purified by crystallisation (ethanol)

실험 절차

0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).

출처