반응 #82833

반응 방정식

sodium methoxide

1-benzyl-4-ethoxycarbonylpiperidine

formamide

→

1-benzyl-4-carbamoylpiperidine

용매

methanol

N,N-dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring at 100° C. for 1 hour
2. 2
   기타the mixture was evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
4. 4
   세척washed with water and brine
5. 5
   건조dried over magnesium sulfate
6. 6
   기타evaporated in vacuo
7. 7
   기타The residue was recrystallized from ether

실험 절차

To a mixture of 1-benzyl-4-ethoxycarbonylpiperidine (6.88 g) and formamide (3.71 ml) in N,N-dimethylformamide (30 ml) was added 28% sodium methoxide solution in methanol (4.0 ml) at 100° C. under stirring. After stirring at 100° C. for 1 hour, the mixture was evaporated in vacuo. The residue was dissolved in ethyl acetate and washed with water and brine and dried over magnesium sulfate, and evaporated in vacuo. The residue was recrystallized from ether to give 1-benzyl-4-carbamoylpiperidine (2.8 g).

출처