반응 #82827

반응 방정식

N-[2-[1-(4-fluorobenzyl)piperidin-4-yl]ethyl]phthalimide

hydrazine hydrate

→

2-[1-(4-fluorobenzyl)piperidin-4-yl]ethylamine

수율 54.9%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 2 hours
2. 2
   기타the mixture was evaporated in vacuo
3. 3
   기타The residue was chromatographed on alumina eluting with chloroform
4. 4
   workup.ADDITIONthe fractions containing the object product
5. 5
   기타were collected
6. 6
   기타evaporated

실험 절차

A mixture of N-[2-[1-(4-fluorobenzyl)piperidin-4-yl]ethyl]phthalimide (12.7 g) and hydrazine hydrate (2.02 ml) in ethanol (150 ml) was refluxed for 2 hours. After cooling to room temperature, the mixture was evaporated in vacuo. The residue was chromatographed on alumina eluting with chloroform and the fractions containing the object product were collected and evaporated to give 2-[1-(4-fluorobenzyl)piperidin-4-yl]ethylamine (4.5 g) as an oil.

출처