반응 #82816

반응 방정식

1-benzyl-4-(4-cyanobutyl)piperidine

potassium carbonate

hydroxylamine hydrochloride

→

5-(1-benzylpiperidin-4-yl)-1-hydroxyiminopentylamine

수율 62.8%

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 20 hours
3. 3
   온도After cooling
4. 4
   여과the mixture was filtered
5. 5
   기타evaporated in vacuo
6. 6
   workup.DISSOLUTIONThe residue was dissolved in ether
7. 7
   여과filtered
8. 8
   기타recrystallized

실험 절차

A mixture of 1-benzyl-4-(4-cyanobutyl)piperidine (2.20 g), potassium carbonate (3.56 g) and hydroxylamine hydrochloride (2.39 g) was heated under reflux for 20 hours. After cooling, the mixture was filtered and evaporated in vacuo. The residue was dissolved in ether, filtered and recrystallized to afford 5-(1-benzylpiperidin-4-yl)-1-hydroxyiminopentylamine (1.56 g).

출처