반응 #82815

반응 방정식

1-benzyl-4-(4-cyanobutylidene)piperidine

→

1-benzyl-4-(4-cyanobutyl)piperidine

수율 56.4%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   여과After the catalyst was filtered out
2. 2
   기타the filtrate was evaporated in vacuo
3. 3
   기타The residue was chromatographed on silica gel eluting with chloroform/methanol (95:5)
4. 4
   workup.ADDITIONthe fractions containing the object compound
5. 5
   기타evaporated

실험 절차

A mixture of 1-benzyl-4-(4-cyanobutylidene)piperidine (8.8 g) and platinum dioxide (1.2 g) in tetrahydrofuran (150 ml) was hydrogenated at atmospheric pressure for 12 hours. After the catalyst was filtered out, the filtrate was evaporated in vacuo. The residue was chromatographed on silica gel eluting with chloroform/methanol (95:5) and the fractions containing the object compound were combined and evaporated to afford 1-benzyl-4-(4-cyanobutyl)piperidine (5.0 g) as an oil.

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