반응 #82742

반응 방정식

cyanogen bromide

4-isopropylaniline

→

4-isopropylphenyl cyanamide

수율 84.0%

용매

diethylether

diethylether

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was kept stirring at room temperature for 18 h
3. 3
   기타Then a solution with white precipitates
4. 4
   기타formed
5. 5
   기타the precipitates were removed by filtration
6. 6
   세척The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
7. 7
   건조dried over MgSO4
8. 8
   여과filtered
9. 9
   농축concentrated
10. 10
    기타dried under vacuum

실험 절차

A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).

출처