반응 #82703

ord-7f7b3066bbb14fee89758dd2e71988a4

반응 방정식

Clc1ccc(Cl)nn1
3,6-dichloropyridazine
CC1CCCN(C)C1(C)C.[Li]
lithium tetramethylpiperidine
CCC[CH2][Sn]([Cl])([CH2]CCC)[CH2]CCC
tributyltin chloride
CCC[CH2][SnH]([CH2]CCC)[CH2]CCC.Clc1ccc(Cl)nn1
3,6-dichloropyridazine tributylstannane

용매

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    온도to warm slowly overnight

실험 절차

A THF solution (10 mL) of 3,6-dichloropyridazine (16.8 mmol, 2.5 g) was added dropwise to a solution of lithium tetramethylpiperidine (20.1 mmol) in 170 mL of THF at -78° C. After one hour at -78° C., tributyltin chloride (21.8 mmol, 5.8 mL) was added to the anion solution and the solution was allowed to warm slowly overnight.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05622967uspto-grants-1997_04