반응 #82642

반응 방정식

2-acetamido-5-fluorobenzotrifluoride

HNO3

→

2-acetamido-5-fluoro-3-nitrobenzotrifluoride

용매

H2SO4

반응 조건

후처리

1. 1
   workup.WAITat room temperature for 3 h
2. 2
   여과The precipitate was collected by filtration

실험 절차

To 2-acetamido-5-fluorobenzotrifluoride (1.369 g, 6.19 mmol) in concentrated H2SO4 (6 mL) at 0° C. was added dropwise 70% HNO3 (0.8 mL, Baker). The mixture was stirred at 0° C. for 0.5 h, then at room temperature for 3 h and it was poured into ice water (25 g). The precipitate was collected by filtration, affording 2.1 g of crude 2-acetamido-5-fluoro-3-nitrobenzotrifluoride. It was crystallized from EtOH/H2O to afford 1.50 g of pure compound as yellow needles.

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