반응 #82546

반응 방정식

2,4-diamino-5-iodo-6-methylpyrimidine

1-fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene

tri-2-furylphosphine

→

2,4-diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   기타This compound is prepared in a manner analogous to that of Step E of Example 4

실험 절차

This compound is prepared in a manner analogous to that of Step E of Example 4, using 1.2 grams (0.0048 mole) of 2,4-diamino-5-iodo-6-methylpyrimidine, 2.3 grams (0.0048 mole) of 1-fluoro-3-(4-chlorophenyl)-3-methyl-1-tributylstannyl-1-butene, 0.04 gram of tri-2-furylphosphine, 0.04 gram of tris(dibenzylidineacetone)dipalladium(0) in about 30 mL of N,N-dimethylformamide, yielding 2,4-diamino-6-methyl-5-[1-fluoro-3-methyl-3-(4-chlorophenyl)-1-butenyl]pyrimidine.

출처