반응 #82544

반응 방정식

3-(4-chlorophenyl)-3-methylbutyraldehyde

fluoromethyl phenyl sulfone

diethyl chlorophosphate

ammonium chloride

hydrochloric acid

lithium bis(trimethylsilyl)amide

→

1-fluoro-1-phenylsulfonyl-3-methyl-3-(4-chlorophenyl)-1-butene

용매

tetrahydrofuran

tetrahydrofuran

ethyl acetate

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONUpon completion of addition
2. 2
   workup.ADDITIONUpon completion of addition
3. 3
   온도to warm to ambient temperature where it
4. 4
   workup.STIRRINGis stirred for about two hours
5. 5
   기타The organic layer is separated
6. 6
   추출the aqueous o layer is extracted with ethyl acetate
7. 7
   추출The extract
8. 8
   세척washed with 100 mL of saturated aqueous sodium chloride
9. 9
   건조dried with magnesium sulfate
10. 10
    여과The mixture is filtered
11. 11
    농축the filtrate is concentrated under reduced pressure to a residue
12. 12
    농축concentrated under reduced pressure

실험 절차

Under a nitrogen atmosphere, 25.0 grams (0.14 mole) of distilled fluoromethyl phenyl sulfone (prepared by the method of J. R McCarthy et al., Org. Syn. 1993, 72, 209), 24.8 grams (0.14 mole) of diethyl chlorophosphate, and 300 mL of anhydrous tetrahydrofuran are placed in a reaction vessel. The stirring mixture is cooled to about -70° C., and a solution of 310 mL (0.31 mole) of lithium bis(trimethylsilyl)amide (commercially available-1M in tetrahydrofuran) is added dropwise during a 15 minute period. Upon completion of addition, the reaction mixture is stirred at about -70° C. for one hour. After this time a solution of 19.7 grams (0.10 mole) of 3-(4-chlorophenyl)-3-methylbutyraldehyde in 65 mL of tetrahydrofuran is added via a syringe. Upon completion of addition, the reaction mixture is allowed to warm to ambient temperature where it is stirred for about two hours. The reaction mixture is then poured into an ice-cold mixture of 250 mL of ethyl acetate, 250 mL of saturated aqueous ammonium chloride, and 30 mL of concentrated hydrochloric acid. The organic layer is separated, and the aqueous o layer is extracted with ethyl acetate. The extract and the organic layer are combined, washed with 100 mL of saturated aqueous sodium chloride, and dried with magnesium sulfate. The mixture is filtered, and the filtrate is concentrated under reduced pressure to a residue. The residue is subjected to column chromatography on silica gel. The product-containing fractions are combined and concentrated under reduced pressure, yielding 1-fluoro-1-phenylsulfonyl-3-methyl-3-(4-chlorophenyl)-1-butene.

출처