반응 #82516

반응 방정식

N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane

isoamylamine

→

N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine

수율 81.0%

용매

isopropyl alcohol

반응 조건

후처리

1. 1
   온도to reflux for 2.5 hours
2. 2
   농축concentrated in vacuo
3. 3
   기타recrystallized
4. 4
   기타The product was isolated by filtration and from ethylacetate/hexane

실험 절차

A solution of N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane (30.1 g, 0.10 mol) and 165 mL isoamylamine in 150 mL of isopropyl alcohol was heated to reflux for 2.5 hours. The solution was cooled to room temperature, concentrated in vacuo and then recrystallized. The product was isolated by filtration and from ethylacetate/hexane to afford 31.7 g (81%) of N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine.

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