반응 #82463

반응 방정식

Diethyl 5-amino-1,6-dihydro-6-oxo-pyridine-2,3-dicarboxylate

triethylorthopropionate

p-toluenesulfonic acid

→

diethyl 2-ethyloxazolo[5,4-b]pyridine-5,6-dicarboxylate

수율 84.8%

반응 조건

후처리

1. 1
   온도the mixture is heated
2. 2
   온도at reflux for 65 hours
3. 3
   기타The triethyorthopropionate is removed in vacuo
4. 4
   기타the resulting oil is purified by column chromatography
5. 5
   workup.ADDITIONThe tractions containing the pure desired product

실험 절차

Diethyl 5-amino-1,6-dihydro-6-oxo-pyridine-2,3-dicarboxylate (7.57 g, 0.030 mol), is suspended in 60 mL triethylorthopropionate (TEOP 0.30 mol). A small amount of p-toluenesulfonic acid is added and the mixture is heated at reflux for 65 hours. The triethyorthopropionate is removed in vacuo and the resulting oil is purified by column chromatography. The tractions containing the pure desired product are combined and striped to a honey-colored oil weighing 7.38 g, yield 84.8%.

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