반응 #82450

반응 방정식

Diethyl 6-amino-5-nitro-2,3-pyridinedicarboxylate

hydrogen

→

product

수율 94.5%

Diethyl 5,6-diamino-2,3-pyridinedicarboxylate

수율 94.5%

용매

ethanol

반응 조건

후처리

1. 1
   기타The catalyst is removed by filtration through a pad of Celite
2. 2
   농축the filtrate is concentrated

실험 절차

Diethyl 6-amino-5-nitro-2,3-pyridinedicarboxylate (5.00 g, 0.0176 mol) is suspended in 250 mL of absolute ethanol and the mixture cooled to 0° C. Palladium on carbon (50 g of 10% is added and the mixture is shaken under 50 psi hydrogen in a Parr apparatus for four hours. The catalyst is removed by filtration through a pad of Celite, and the filtrate is concentrated to yield 4.21 g (94.2%) of product as a yellow solid, melting point 143°-146.5° C.

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