반응 #8232

반응 방정식

methyl 4-({(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenyl-ethenyl]benzyl}oxy)phenethyl]amino)methyl)benzoate

hydrogen

→

Methyl 4-[((5-methoxy-5-oxopentyl){2-{(4-phenethylbenzyl)oxy]-phenethyl}amino)methyl]benzoate

용매

ethyl acetate

반응 조건

후처리

1. 1
   여과The solution is filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   기타The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate=10:1

실험 절차

781.8 mg (1.34 mmol) of methyl 4-({(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenyl-ethenyl]benzyl}oxy)phenethyl]amino)methyl)benzoate from Ex. 6 and 80.0 mg of 10% palladium on activated carbon in 10 ml of ethyl acetate are hydrogenated under atmospheric pressure. After 1 hour, the calculated amount of hydrogen has been taken up. The solution is filtered and the solvent distilled off under reduced pressure. The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate=10:1.

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