반응 #823129

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ethyl[(4-bromobenzyl)(4-oct-1-ynylbenzyl)amino](oxo)acetate

1-octyne

→

title compound

수율 32.0%

ethyl[bis(4-oct-1-ynylbenzyl)amino](oxo)acetate

수율 32.0%

반응 조건

후처리

1. 1
   기타The same procedure as employed in the preparation of Example 226 (step c)

실험 절차

The same procedure as employed in the preparation of Example 226 (step c) but using ethyl[(4-bromobenzyl)(4-oct-1-ynylbenzyl)amino](oxo)acetate and 1-octyne gave the title compound as a pale yellow oil (32%). 1H NMR (CDCl3, 300 MHz) δ 7.38 (m, 4H), 7.16 (d, 2H, J=8.3 Hz), 7.12 (d, 2H, J=7.9 Hz), 4.45 (s, 2H), 4.35 (q, 2H, J=7.2 Hz), 4.28 (s, 2H), 2.42 (t, 4H, J=7.1 Hz), 1.62 (m, 4H), 1.47 (m, 4H), 1.33 (m, 11H), 0.92 (t, 6H, J=6.8 Hz). M+(LC/MS(ESI)): 514.0. HPLC (Condition A), Rt: 6.54 min (HPLC purity: 99.3%).

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