반응 #8231

반응 방정식

methyl 4-{[(2-hydroxyphenethyl)-(5-methoxy-5-oxopentyl)-amino]methyl}benzoate

4-(chloromethyl)stilbene

potassium carbonate

→

Methyl 4-({(5-methoxy-5-oxopentyl)[2-({4-[(E)-2-phenylethenyl]benzyl}-oxy)phenethyl]amino}methyl)benzoate

용매

acetonitrile

반응 조건

후처리

1. 1
   온도at reflux for 18 hours
2. 2
   여과The solution is filtered
3. 3
   workup.DISTILLATIONthe solvent is distilled off under reduced pressure
4. 4
   기타The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate 4/1

실험 절차

1.0 g (2.50 mmol) of methyl 4-{[(2-hydroxyphenethyl)-(5-methoxy-5-oxopentyl)-amino]methyl}benzoate from Ex. 1, 0.687 g (3.00 mmol) of 4-(chloromethyl)stilbene and 0.520 g (3.75 mmol) of potassium carbonate in 10.0 ml of acetonitrile are heated at reflux for 18 hours. The solution is filtered and the solvent is distilled off under reduced pressure. The crude product is purified by chromatography over silica gel using the mobile phase cyclohexane/ethyl acetate 4/1.

출처