반응 #82263

반응 방정식

3,4-diaminobenzonitrile

ethyl chloroacetoimidate hydrochloride

→

2-chloromethyl-5-benzimidazolecarbonitrile

수율 54.9%

용매

ethanol

반응 조건

후처리

1. 1
   온도the solution was refluxed
2. 2
   온도under heating for 3 hours
3. 3
   온도After cooling
4. 4
   workup.DISTILLATIONdistilling off the solvent
5. 5
   workup.DISSOLUTIONthe resulting residue was dissolved in ethyl acetate
6. 6
   세척washed with water
7. 7
   기타dried
8. 8
   workup.DISTILLATIONAfter distilling off the solvent
9. 9
   기타the crystals thus precipitated
10. 10
    여과were collected by filtration

실험 절차

3.42 g of 3,4-diaminobenzonitrile and 4.06 g of ethyl chloroacetoimidate hydrochloride were dissolved in 100 ml of ethanol, and the solution was refluxed under heating for 3 hours. After cooling and distilling off the solvent, the resulting residue was dissolved in ethyl acetate, washed with water, and then dried. After distilling off the solvent, the crystals thus precipitated were collected by filtration to obtain 2.7 g of 2-chloromethyl-5-benzimidazolecarbonitrile.

출처