반응 #82243

반응 방정식

5-bromosalicylaldehyde

2-bromo-4-methoxyacetophenone

potassium carbonate

→

5-bromo-2-(4-methoxybenzoyl)benzofuran

수율 42.6%

용매

acetone

반응 조건

후처리

1. 1
   기타the resulting reaction solution
2. 2
   농축was concentrated to dryness
3. 3
   workup.ADDITIONmixed with water
4. 4
   기타to collect
5. 5
   기타precipitated crystals
6. 6
   여과by filtration
7. 7
   세척After washing with water and subsequent recrystallization from ethanol

실험 절차

To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.

출처