반응 #822406

반응 방정식

2-amino benzoic acid methyl ester

2-phenyl-propionic acid

n-hexane

SOCl2

→

compound

수율 82.1%

4-chloro-2-(2-phenyl-propionylamino)-benzoic acid methyl ester

수율 82.1%

용매

EtOAc

반응 조건

실험 절차

The objective compound was prepared by the same procedure for the intermediate 1, using a 2-phenyl-propionic acid (2.00 g, 13.3 mmol), SOCl2 (2.88 mL, 40.0 mmol) and 2-amino benzoic acid methyl ester (1.72 g, 9.31 mmol). After normal workup, the pure objective compound (2.43 g, 82%) was obtained as a pale yellow syrup by a flash column chromatography (n-hexane:EtOAc=20:1): 1H-NMR (200 MHz, CDCl3) δ 1.61 (d, J=6.92 Hz, 3H, CH3), 3.72-3.85 (m, 4H, OCH3, CH), 6.95 (d, J=2.03 Hz, 1H, ArH), 6.99 (d, J=2.03 Hz, 1H, ArH), 7.24-7.45 (m, 5H, ArH), 7.84 (d, J=8.55 Hz, 1H, ArH), 8.84 (d, J=2.03 Hz, 1H, ArH), 11.15 (br s, 1H, NH).

출처