반응 #821671

반응 방정식

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

1,1-Dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate

trifluoroacetic acid

→

title compound

수율 96.0%

2-Methyl-5-(1-piperazinyl)quinoline

수율 96.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure

실험 절차

1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).

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