반응 #82154

반응 방정식

7-benzyl-1-cyano-2-oxa-7-aza-bicyclo[3.3.0]octane

lithium aluminium hydride

water

potassium hydroxide

water

→

1-Aminomethyl-7-benzyl-2-oxa-7-aza-bicyclo[3.3.0]octane

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도under reflux for 15 hours
2. 2
   여과the inorganic salts are filtered off with suction
3. 3
   농축the filtrate is concentrated
4. 4
   workup.DISTILLATIONdistilled

실험 절차

10.2 g (40 mmol, 90% pure) of 7-benzyl-1-cyano-2-oxa-7-aza-bicyclo[3.3.0]octane are added dropwise to 2 g of lithium aluminium hydride in 100 ml of absolute tetrahydrofuran and the mixture is subsequently stirred under reflux for 15 hours. 2 ml each of water, 15% strength potassium hydroxide solution, and again water, are added dropwise, the inorganic salts are filtered off with suction, and the filtrate is concentrated and distilled. Yield: 7.7 g (83% of theory).

출처