반응 #82084

반응 방정식

1-acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene

→

2-nitro-3,5-bis(trifluoromethyl)aniline

수율 71.2%

용매

HCl

EtOH

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   추출it was extracted by ethyl acetate (2×3 mL)
3. 3
   건조The extract was dried over Mg2SO4
4. 4
   기타evaporated

실험 절차

A mixture of 1-acetamido-2-nitro-3,5-bis(trifluoromethyl)benzene (200 mg, 0.63 mmol) in concentrated HCl (3 mL) and EtOH (3 mL) was refluxed overnight, then it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 2-nitro-3,5-bis(trifluoromethyl)aniline 123 mg (71%). 1H NMR (DMSO-d6): δ 6.392 (s, 2H), 7.131 (s, 1H), 7.375 (s, 1H).

출처