반응 #82074

반응 방정식

HNO3

3-chloro-2,4-difluoro(trifluoroacetamido)benzene

HNO3

→

solid

수율 95.0%

3-Chloro-2,4-difluoro-6-nitro-(trifluoroacetamido)benzene

수율 95.0%

용매

H2SO4

반응 조건

후처리

1. 1
   여과The precipitate was filtered
2. 2
   세척washed by water
3. 3
   기타dried

실험 절차

To a solution of 15.1 g (58.1 mmol) of 3-chloro-2,4-difluoro(trifluoroacetamido)benzene in 80 mL of H2SO4 kept in an ice-bath was added dropwise 10 mL of HNO3. Solid precipitate was observed during addition of HNO3. The mixture was stirred in an ice-bath for 4 h. It was added into 600 mL of ice-water. The precipitate was filtered and washed by water, and dried to leave almost colorless solid (16.8 g, 95%), mp 124°-125° C. 1H NMR (CDCl3), 7.69 (dd, 1), 8.936 (mb, 1).

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