반응 #82033

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5-nitro-6,7-dibromo-1,4-dihydro-2,3-quinoxalinedione

SnCl2.2H2O

→

pure title product

수율 64.7%

5-Amino-6,7-dibromo-1,4-dihydro-2,3-quinoxalinedione

수율 64.7%

용매

ethanol

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후처리

1. 1
   온도The mixture was then cooled to room temperature
2. 2
   여과the yellow precipitate was collected by filtration
3. 3
   세척by washing with cold ethanol (2×1 mL)
4. 4
   기타to get 227 mg (76%) of crude title product (contains minor impurities by NMR)
5. 5
   기타Crystallization from DMSO/H2O

실험 절차

To a stirred mixture of 5-nitro-6,7-dibromo-1,4-dihydro-2,3-quinoxalinedione (327 mg, 0.89 mMol) in ethanol (10 mL) was added SnCl2.2H2O (1.0 g, 4.45 mMol) in one portion. The mixture was refluxed at 80° C. (oil bath 90° C.) with stirring for 4 h. The mixture was then cooled to room temperature and the yellow precipitate was collected by filtration, followed by washing with cold ethanol (2×1 mL), to get 227 mg (76%) of crude title product (contains minor impurities by NMR). Crystallization from DMSO/H2O gave 193 mg of pure title product as bright yellow needles; mp: 324°-6° C. (dec.), changed color from 270° C. IR (KBr, cm-1): 3456; 3281; 1700; 1643. NMR (1H, DMSO-d6): d 5.844 (s, 2H); 6.732 (s, 1H); 11.257 (s, 1H); 11.810 (s, 1H). Purity: >96.96% by HPLC. HRMS: calcd for C8H8N3O2Br2 (M+) m/z 332.8747; found: 332.8754. Potency relative to DCK: 341%.

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