반응 #8198

반응 방정식

3-Methylbenzo[b]thiophene

n-bromosuccinimide

2,2′Azobisisobutyronitrile

→

3-Bromomethylbenzo[b]thiophene

수율 42.2%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도the resulting mixture is refluxed for two hours
2. 2
   온도After cooling
3. 3
   여과the reaction mixture is filtered through a glass-fritted funnel
4. 4
   농축the filtrate is concentrated
5. 5
   기타The residue is triturated with petroleum ether and toluene

실험 절차

3-Methylbenzo[b]thiophene (9.9 g, 67 mmol) is heated in carbon tetrachloride (133 ml ) to near reflux in the presence of n-bromosuccinimide (11.9 g, 67 mmol, 1.0 eq.). 2,2′Azobisisobutyronitrile (2.2 g, 13.3 mmol, 0.2 eq.) is added and the resulting mixture is refluxed for two hours. After cooling, the reaction mixture is filtered through a glass-fritted funnel, and the filtrate is concentrated. The residue is triturated with petroleum ether and toluene to afford 6.42 g of 3-Bromomethylbenzo[b]thiophene (42%).

출처