반응 #818616

ord-c689fd1cce2a4700b7944c66c9352dd4

반응 방정식

CC[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCC2)CC1
{2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid
CC(C)(C)C1CCC(NC2CCCCCC2)CC1
(4-tert-butyl-cyclohexyl)-cycloheptyl-amine
CCOC(=O)CSc1cnc(N)s1
(2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester
→
CC(C)(C)[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCCCC2)CC1
title compound
CC(C)(C)[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCCCC2)CC1
{2-[3-(trans-4-tert-Butyl-cyclohexyl)-3-cycloheptyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid

반응물

CC[C@H]1CC[C@H](N(C(=O)Nc2ncc(SCC(=O)O)s2)C2CCCC2)CC1
{2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid
CC(C)(C)C1CCC(NC2CCCCCC2)CC1
(4-tert-butyl-cyclohexyl)-cycloheptyl-amine
CCOC(=O)CSc1cnc(N)s1
(2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Prepared in a similar manner to {2-[3-cyclopentyl-3-(trans-4-ethyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid via (4-tert-butyl-cyclohexyl)-cycloheptyl-amine and (2-amino-thiazol-5-ylsulfanyl)-acetic acid ethyl ester to give the title compound.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07582769B2uspto-grants-2009_09