반응 #81729

ord-44631a82b5b94d1fa39a8991bac6e21a

반응 방정식

[Br][Mg][c]1ccc2c(c1)OCO2
3,4-methylenedioxyphenylmagnesium bromide
COC(=O)c1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)c3ccccc3)CC[C@@H]12
( iv )
COC(=O)c1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)c3ccccc3)CC[C@@H]12
Methyl 17β-benzoyl-estra-1,3,5(10)-triene-3-carboxylate
→
C[C@]12CC[C@@H]3c4ccc(C(=O)O)cc4CC[C@H]3[C@@H]1CC[C@@H]2C(=O)c1ccc2c(c1)OCO2
title compound
C[C@]12CC[C@@H]3c4ccc(C(=O)O)cc4CC[C@H]3[C@@H]1CC[C@@H]2C(=O)c1ccc2c(c1)OCO2
17β-(3,4-Methylenedioxybenzoyl)-estra-1,3,5(10)-triene-3-carboxylic acid

반응물

[Br][Mg][c]1ccc2c(c1)OCO2
3,4-methylenedioxyphenylmagnesium bromide
COC(=O)c1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)c3ccccc3)CC[C@@H]12
( iv )
COC(=O)c1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)c3ccccc3)CC[C@@H]12
Methyl 17β-benzoyl-estra-1,3,5(10)-triene-3-carboxylate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared by the method of Example 19 (iv) by replacing benzylmagnesium chloride with 3,4-methylenedioxyphenylmagnesium bromide.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05618806uspto-grants-1997_04