반응 #81707

반응 방정식

sodium hydrogencarbonate

4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline

thionyl chloride

→

title compound

수율 98.7%

4,4-dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline

수율 98.7%

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONwas dropwise added
2. 2
   기타The reaction liquid
3. 3
   추출followed by the extraction with methylene chloride
4. 4
   세척After washing with water
5. 5
   기타drying
6. 6
   농축vacuum concentration

실험 절차

1.0 g (3.55 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline was dissolved in methylene chloride (15 ml). Under cooling with ice, 0.51 g (4.29 mmol) of thionyl chloride was dropwise added thereto, followed by stirring for one hour. The reaction liquid was poured into an aqueous solution of sodium hydrogencarbonate, followed by the extraction with methylene chloride. After washing with water and drying, vacuum concentration was conducted. 1.05 g of the title compound was obtained as a crystal (yield 99%).

출처