반응 #816802

반응 방정식

HCl

dioxane

4-(4-{3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-ureido}-isoquinolin-1-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

→

title compound

1-[5-(1-Methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[1-(piperidin-4-yloxy)-isoquinolin-4-yl]-urea dihydrochloride

용매

dichloromethane

반응 조건

후처리

1. 1
   기타Evaporate the solvent under reduced pressure

실험 절차

Add HCl 4 M in dioxane (2.4 mL, 9.36 mmol) to 4-(4-{3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-ureido}-isoquinolin-1-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1.4 g, 2.34 mmol) in dichloromethane (20 mL) at room temperature and stir overnight. Evaporate the solvent under reduced pressure to give the title compound (1.3 g) as a white solid (quantitative). ES+ (m/z): 497.4 (M+H).

출처