반응 #816436

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n-Butylamine

((4-Chlorophenyl)methyl)sulfonyl chloride

→

title compound

수율 93.4%

N-Butyl-1-(4-chlorophenyl)methanesulfonamide

수율 93.4%

용매

THF

THF

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후처리

1. 1
   온도it was then cooled in an ice-bath
2. 2
   기타The cooling-bath was removed
3. 3
   workup.ADDITIONafter the addition
4. 4
   기타evaporated to dryness
5. 5
   workup.ADDITIONDCM (50 mL) was added to the residue
6. 6
   세척It was washed with HCl (5%, 10 mL), water (30 mL×3) and brine (20 mL)
7. 7
   건조dried (MgSO4)
8. 8
   기타evaporated

실험 절차

n-Butylamine (3.25 g, 44.43 mmol) was dissolved in THF (25 mL) and it was then cooled in an ice-bath. ((4-Chlorophenyl)methyl)sulfonyl chloride (5.0 g, 22.21 mmol) in THF (25 mL) was dropped in. The cooling-bath was removed after the addition. The mixture was stirred for 2 h and then evaporated to dryness. DCM (50 mL) was added to the residue. It was washed with HCl (5%, 10 mL), water (30 mL×3) and brine (20 mL), dried (MgSO4) and evaporated to give the title compound (5.43 g, 93%) as a solid; 1H NMR (400 MHz, CDCl3): δ 7.36 (d, 2H), 7.32 (d, 2H), 4.19 (s, 2H), 4.11 (bt, 1H), 2.99 (dd, 2H), 1.50-1.43 (m, 2H), 1.36-1.26 (m, 2H), 0.90 (t, 3H); Mass Spectrum: M−H+ 260.

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