반응 #81643

반응 방정식

carbon monoxide

methyl 3-carbamoylisobutyrate

methyl formate

carbon monoxide

→

dimethyl methylsuccinate

formamide

용매

methanol

methanol

반응 조건

후처리

1. 1
   온도with heating
2. 2
   온도to maintain the internal pressure at 40 kg/cm2G
3. 3
   기타reached 60° C.
4. 4
   온도to maintain the internal pressure at 40 kg/cm2G
5. 5
   기타to proceed with the reaction for 3 hours
6. 6
   온도Subsequently, the content therein was cooled
7. 7
   기타As a result of analysis

실험 절차

The procedure in Example 3 (3) was repeated to proceed with heating stirring reaction except that in place of 180 g of methyl formate and 96 g of methanol, 200 g of methanol was charged in the autoclave and carbon monoxide was pressurized into the autoclave so as to maintain the internal pressure at 40 kg/cm2G. After the temperature of the content in the autoclave reached 60° C., carbon monoxide was fed in the autoclave so as to maintain the internal pressure at 40 kg/cm2G to proceed with the reaction for 3 hours. Subsequently, the content therein was cooled, internal pressure was gradually lowered to atmospheric pressure, and the reaction product was taken out. As a result of analysis therefor, the conversion of methyl 3-carbamoylisobutyrate was 81.4% and there were obtained dimethyl methylsuccinate at a selectivity of 95.7% and formamide at a selectivity of 94.4%, each based on the reacted methyl 3-carbamoylisobutyrate.

출처