반응 #81611

반응 방정식

ethyl 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoate

sodium hydroxide

→

title compound

수율 82.6%

3-[2-[(4-Chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoic acid

수율 82.6%

용매

methanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 1 hour
3. 3
   기타evaporated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in a small volume of water
5. 5
   추출The resulting mixture was extracted several times with ether
6. 6
   건조the combined extracts were dried (MgSO4)
7. 7
   기타evaporated

실험 절차

A mixture of ethyl 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoate (500 mg), 2N sodium hydroxide solution (1.5 ml) and methanol (5 ml) was heated under reflux for 1 hour and then evaporated. The residue was dissolved in a small volume of water, and the solution was made acidic with 2N hydrochloric acid. The resulting mixture was extracted several times with ether and the combined extracts were dried (MgSO4) and evaporated to give the title compound,(390 mg), m.p. 85°-87° C. Found: C,60.78A H,5.06; N,2.87. C24H33ClFNO4S requires C,60.56; H,4.87; N,2.94%.

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