반응 #816017

반응 방정식

1-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-[4-(2-methoxyethyl)phenoxy]-2-propanol

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title compound

1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]-3-[4-(2-methoxyethyl)phenoxy]-2-propanol

용매

HCl

반응 조건

후처리

1. 1
   기타remove the solvents in vacuo
2. 2
   workup.DISSOLUTIONDissolve the residue in glacial acetic acid with 0.86 g10% palladium hydroxide on carbon
3. 3
   기타the progress of the reaction by thin-layer chromatography on silica gel (acetonitrile:ammonia,9:1)
4. 4
   기타At the completion of the reaction
5. 5
   여과the catalyst is filtered
6. 6
   기타the solvents are removed in vacuo
7. 7
   기타The resulting oil is chromatographed on alumina (activity III)

실험 절차

Dissolve 6.36 g (.013 mol) 1-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-[4-(2-methoxyethyl)phenoxy]-2-propanol in 50 mL 5 M methanolic HCl and remove the solvents in vacuo. Dissolve the residue in glacial acetic acid with 0.86 g10% palladium hydroxide on carbon. The reaction mixture is hydrogenated under 52 psi H2 on a Parr Hydrogenator. Follow the progress of the reaction by thin-layer chromatography on silica gel (acetonitrile:ammonia,9:1). At the completion of the reaction, the catalyst is filtered and the solvents are removed in vacuo. The resulting oil is chromatographed on alumina (activity III) using 2% methanol in methylene chloride to provide the title compound.

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