반응 #816016

반응 방정식

2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-(2-methoxyphenyl)ethanone

→

title compound

α-[[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]methyl]-2-methoxybenzenemethanol

용매

HCl

methanol

반응 조건

후처리

1. 1
   기타remove the solvents in vacuo
2. 2
   workup.DISSOLUTIONDissolve the residue in 50 mL H2O with 0.85 9 10% palladium hydroxide on charcoal
3. 3
   기타for 20 h
4. 4
   여과After this time, filter the catalyst
5. 5
   기타remove the solvents
6. 6
   기타Recrystallize the solid from ethanol

실험 절차

Dissolve 3.8 9 2-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-1-(2-methoxyphenyl)ethanone in 50 mL 5 M HCl in methanol and remove the solvents in vacuo. Dissolve the residue in 50 mL H2O with 0.85 9 10% palladium hydroxide on charcoal. Hydrogenate the solution under 52 psi hydrogen for 20 h. After this time, filter the catalyst and remove the solvents to givethe crude product. Recrystallize the solid from ethanol to give the title compound.

출처