반응 #816000

반응 방정식

1,2-epoxy-3-phenoxypropane

2-[4-(1H-imidazol-1-yl)phenoxy]-N-(phenylmethyl)ethanamine

→

title compound

1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol

용매

MeOH

반응 조건

후처리

1. 1
   기타the progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1)
2. 2
   기타At the completion of the reaction
3. 3
   기타evaporate the solvents
4. 4
   기타The resulting oil is chromatographed on a silica gel column
5. 5
   기타Collect the appropriate fractions
6. 6
   기타remove the solvents

실험 절차

To a solution of 3.2 mL (23.9 mmol) 1,2-epoxy-3-phenoxypropane in 20 mL MeOH, add 6.99 g (23.9 mmol) 2-[4-(1H-imidazol-1-yl)phenoxy]-N-(phenylmethyl)ethanamine as the free base described above. Stir at room temperature under a nitrogen atmosphere. Follow the progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1). At the completion of the reaction, evaporate the solvents. The resulting oil is chromatographed on a silica gel column using (petroleum ether :acetone, 8:2). Collect the appropriate fractions and remove the solvents to give the title compound.

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