반응 #815991

반응 방정식

N-[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]propionamide

hydrochloric acid

→

title compound

2-[4-(1H-Imidazol-1-yl)phenoxy]ethanamine dihydrochloride

반응 조건

후처리

1. 1
   온도Reflux the reaction mixture
2. 2
   기타Monitor the progress of the reaction by thin-layer chromatographyon silica gel (9:1, CH2Cl2 :MeOH)
3. 3
   기타Upon completion of the reaction
4. 4
   기타remove the solvent in vacuo
5. 5
   기타triturate with isopropanol
6. 6
   기타Recrystallization of the resulting solid from ethanol

실험 절차

To 40 mL of 2M aqueous hydrochloric acid add 10.3 g (39 mmol) of N-[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl]propionamide. Reflux the reaction mixture. Monitor the progress of the reaction by thin-layer chromatographyon silica gel (9:1, CH2Cl2 :MeOH). Upon completion of the reaction, remove the solvent in vacuo and triturate with isopropanol. Recrystallization of the resulting solid from ethanol affords the title compound.

출처