반응 #81548

반응 방정식

water

terephthaloylchloride

tert-butyl alcohol

→

title compound

Di-tert-butyl terephthalate

용매

pyridine

반응 조건

후처리

1. 1
   여과the solid filtered
2. 2
   workup.DISSOLUTIONThe solid was dissolved in diethyl ether (40 mL)
3. 3
   세척washed with saturated sodium bicarbonate (2×75 mL)
4. 4
   건조The organic phase was then dried over anhydrous magnesium sulfate
5. 5
   농축concentrated in vacuo

실험 절차

To a solution of terephthaloylchloride (2.00 g, 9.85 mmol) in dry pyridine (25.0 mL) was added tert-butyl alcohol (803 mg, 10.8 mmol). After 16 hours at 85° C. water (75.0 mL) was added and the solid filtered. The solid was dissolved in diethyl ether (40 mL) and washed with saturated sodium bicarbonate (2×75 mL). The organic phase was then dried over anhydrous magnesium sulfate and concentrated in vacuo to give 1.15 g (Y: 42%) of the title compound; 1H-NMR (CDCl3): δ8.01 (s, 4H), 1.60 (s, 18H).

출처